Our Science
Type 2 Diabetes
SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia.
Chen Kang¹, Litao Xie¹, Susheel K. Gunasekar¹, Anil Mishra¹, Yanhui Zhang¹, Saachi Pai¹, Yiwen Gao¹, Ashutosh Kumar¹, Andrew W. Norris²,³, Samuel B. Stephens¹,³ & Rajan Sah¹,³,⁴
β-Cells: SWELL1 regulates insulin release and systemic glycemic control.
SWELL1 is a regulator of adipocyte size, insulin signaling and glucose homeostasis
Yanhui Zhang¹, Litao Xie¹, Susheel K. Gunasekar¹, Dan Tong¹, Anil Mishra¹, William J. Gibson², Chuansong Wang³, Trevor Fidler⁴, Brodie Marthaler¹, Aloysius Klingelhutz⁵, E. Dale Abel⁴, Isaac Samuel⁶, Jessica K. Smith⁶, Lei Cao³ and Rajan Sah¹,⁴,⁷
Adipose Cells: SWELL1 regulates insulin signaling and systemic glycemic control.
SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism
Ashutosh Kumar¹, Litao Xie¹, Chau My Ta¹, Antentor O Hinton²,³, Susheel K Gunasekar¹, Rachel A Minerath²,⁴, Karen Shen⁵, Joshua M Maurer¹, Chad E Grueter²,⁴, E Dale Abel²,³, Gretchen Meyer⁵, Rajan Sah¹*
Skeletal Muscle Cells: SWELL1 regulates adiposity and systemic glycemic control.
NASH
Adipose-targeted SWELL1 deletion exacerbates obesity and age-related non-alcoholic fatty liver disease
Susheel K Gunasekar¹, John Heebink¹, Danielle H Carpenterk, Ashutosh Kumar¹, Litao Xie¹, Haixia Zhang¹, Joel D Schilling¹, Rajan Sah¹
Cardiovascular Disease
The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function
Ahmad F Alghanem¹,²†, Javier Abello³, Joshua M Maurer¹, Ashutosh Kumar¹, Chau My Ta¹, Susheel K Gunasekar¹, Urooj Fatima⁴, Chen Kang¹, Litao Xie¹, Oluqaseun Adeola⁴, Megan Riker⁵, Macaulay Elliot-Hudson⁴, Rachel A Minerath⁴, Chad E Grueter⁴, Robert F Mullins⁵, Amber N Stratman³, Rajan Sah¹,⁶*
Vascular Endothelial Cells: SWELL1 regulates eNOS release and vascular function.
SWELL1 in adipose tissue regulates the accumulation of lipid in liver